J. Christopher Hall

University Professor Emeritus
Email: 
jchall@uoguelph.ca

Education

BSc, BSc(Agr), MSc Guelph;
PhD Alberta

 

Research

 

  • Environmental remediation through immunomodulation.
  • Large-scale purification of antibodies.
  • Understanding the influence of co-extractants (matrix effects) on ELISA sensitivity and cross-reactivity which requires genetic manipulation of antibodies.
  • Developing antibodies by genetic manipulation that can be used as mimics of enzyme target sites (i.e. ACCase) for rapid pesticide screening.
  • Developing methods for the in vitro generation of pesticide-specific antibodies through recombinant phage technology.
  • Molecular, biochemical, and physiological basis for resistance of wild mustard biotypes to the auxinic herbicides.
  • Basis for herbicide selectivity in weeds and crops.

 

Publications

 

  • Larsson, P.A.; Puttaswamaiah, S.G.; Ly,C.; Vanerek, A.; Hall, J.C.; Drolet, F. 2012. Filtration, adsorption and immunodetection of virus using polyelectrolyte multilayer-modified paper. Colloids & Surfaces B: Biointerfaces 101: 205-209.
  • Garabagi, F.; Gilbert, E.; Loos, A.; McLean, M.D.; Hall, J.C. 2012. Utility of the P19 suppressor of gene-silencing protein for production of therapeutic antibodies in Nicotiana expression hosts. Plant Biotech. J. 10(9): 1118-1128.

  • McLean, M.D., Chen, R., Yu, D., Mah, K.-Z., Teat, J., Wang, H., Zaplachinski, S., Boothe, J., Hall, J.C. 2012. Purification of therapeutic antibody trastuzumab from genetically modified plants using safflower protein A-oleosin oilbody technology. Transgenic Research. 21:1291-1301. (2012, DOI: 10.1007/S11248-012-9603-5)

  • Karsunke, X.Y.Z., Wang, H., Weber, E., McLean, M.D., Niessner, R., Hall, J.C., Knopp, D. 2012. Development of single-chain variable fragment (scFv) antibodies against hapten benzo[a]pyrene: a binding study. Anal. and BioAnal. Chem.402:499-507.

  • Makvandi-Nejad, S., Hall, J.C. 2011.Selection and expression of recombinant single domain antibodies from a hyper-immunized library against the hapten azoxystrobin.J. Immunological Methods.372: 1-11.

  • Mithila J., Hall, J.C., Johnson, W.G., Kelley, K.B. and Riechers, D.E. 2011.Evolution of resistance to auxinic herbicides: historical perspectives, mechanisms of resistance, and implications for broadleaf weed management in agronomic crops. Weed Sci. 59:445-457.

  • Mithila, J., McLean, M.D., Chen, S. and Hall. J.C. 2012. Development of near-isogenic lines and  identification of markers linked to auxinic herbicide resistance in wild mustard (Sinapis arvensis L.). Pest Management Sci. 68: 548-556.

  • Mayani, M., McLean, M.D., Hall, J.C., Filipe, C.D.M., Ghosh, R.2011.Recovery and isolation of recombinant human monoclonal antibody from transgenic tobacco plants. Biochem. Eng. J. 54: 103-8.

  • Moran, M., Sikkema, P.H., Hall, J.C., Swanton, C.J. 2011 Sodium safens saflufenacil applied postemergence to corn (Zea mays). Weed Science 59: 4-13.

  • Hussack, G., Luo, Y., Veldhuis, L., Hall, J.C., Tanha, J., MacKenzie, R. 2009. Multivalent anchoring and oriented display of single-domain antibodies on cellulose. Sensors. 9: 5351-5367.

  • Doyle, P., Arbabi-Ghahroudib, M., Gaudette, N., Furzer, G., Savard, M.E., Gleddie, S., McLean, M.D., MacKenzie, C.R. and Hall, J.C. 2008. Cloning, expression, and characterization of a single-domain antibody fragment with affinity for 15-acetyl-deoxynivalenol. Molec. Immunol. 45: 3707-3713.
  • Doyle. P.J., Arbabi-Ghahroudi,M., Gaudette, N., Hermans, A., Musa, L., Furzer, G., Savard, M.E., MacKenzie, C.R., Hall, J.C. 2008. Recombinant antibodies with affinity for deoxynivalenol-a novel tool against fusarium head blight. Can. J. Plant Path. 30:351-353.
  • Yu, D; McLean, M; Hall, JC; Ghosh, R 2008. Purification of a human immunoglobulin G1 monoclonal antibody from transgenic tobacco using membrane chromatographic processes. J Chromat A 1187: 128-137.
  • Mithila, J, Swanton C, Blackshaw, R.E., Cathcart, R.J and Hall, J.C. 2008. Physiological basis for reduced glyphosate efficacy on weeds grown under low soil nitrogen. Weed Science. 56: 12-17.
  • Yu, D., McLean, M.D., Hall, J.C. and Ghosh, R. 2008. Purification of monoclonal antibody from tobacco extract using membrane-based bioseparation techniques. J. Membr. Sci. 323: 159-166.
  • Pokorny, N.J., Boulter-Bitzer, J.I., Hall, J.C., Trevors, J.T. and Lee, H. 2008. Inhibition of Cryptosporidium parvum infection of a mammalian cell culture by recombinant scFv antibodies. Antonie van Leeuwenhoek 94: 353-364.